James Ryan will miss Ireland’s showdown with Scotland on Saturday in the Aviva stadium.
A calf issue, means Ryan was not considered as Joe McCarthy comes into the second row. Captain Caelan Doris leads Ireland into the Round 5 showdown.
Jamie Osborne, Rob Baloucoune and Tommy O'Brien start in Ireland's back three, with Stuart McCloskey and Garry Ringrose once again named in the midfield, while Jamison Gibson-Park and Jack Crowley link up in the half-backs.
In the pack, Tom O'Toole, Dan Sheehan and Tadhg Furlong are named in the front row, with McCarthy and Tadhg Beirne in the engine room.
Jack Conan is named to start at blindside flanker, Josh van der Flier at openside and captain Doris completes Ireland's starting team at number eight.
"It is an incredible privilege for the squad to play at home in front of a packed Aviva Stadium with a trophy up for grabs” said Andy Farrell.
“We know about the challenge facing us on Saturday and Scotland will travel with confidence”.
“You'll see two teams who like to attack and we’ll look to implement our game plan to get the performance that we want”.
“When you factor in a loud home support, and with the game taking place on St Patrick’s weekend, it really has all the ingredients for a cracking contest."
Ireland: 15. Jamie Osborne, 14. Rob Baloucoune, 13. Garry Ringrose, 12. Stuart McCloskey, 11. Tommy O’Brien, 10. Jack Crowley, 9. Jamison Gibson-Park, 1. Tom O’Toole, 2. Dan Sheehan, 3. Tadhg Furlong, 4. Joe McCarthy, 5. Tadhg Beirne, 6. Jack Conan, 7. Josh van der Flier, 8. Caelan Doris (C).
Replacements: 16. Rónan Kelleher, 17. Michael Milne, 18. Finlay Bealham, 19. Darragh Murray, 20. Nick Timoney, 21. Craig Casey, 22. Ciaran Frawley, 23. Bundee Aki
