Johnny Sexton will captain Leinster in their opening Champions Cup title defence and will start in a half-back partnership with Luke McGrath against Wasps.
Garry Ringrose comes in to start at outside-centre while Robbie Henshaw is retained in the 12 shirt from last weekend’s win over Munster at Aviva Stadium.
Jordan Larmour comes in to start on the right wing in the only change to the back three from last week.
A new front row of Cian Healy, Seán Cronin and Tadhg Furlong will start Friday night’s European opener at the RDS.
Devin Toner and James Ryan will once again start in the second row for Leinster Rugby.
In the back row, Dan Leavy moves from openside to blindside, Josh van der Flier comes in to start, and Jack Conan is named at number 8.
Joe Tomane is named among the replacements and could make his European debut for the province if called upon.
Leinster: Rob Kearney, Jordan Larmour, Garry Ringrose, Robbie Henshaw, James Lowe, Johnny Sexton (C), Luke McGrath, Cian Healy, Seán Cronin, Tadhg Furlong, Devin Toner, James Ryan, Dan Leavy, Josh van der Flier, Jack Conan
Replacements: James Tracy, Jack McGrath, Andrew Porter, Scott Fardy, Seán O’Brien, Nick McCarthy, Ross Byrne, Joe Tomane